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1

Potential Applications of Gene Therapy in the Patient with Cancer

Dr Piotr W. Szlosarek, Angus G. Dalgleish

Journal:

Year:

2000

Language:

english

File:

PDF, 185 KB

english, 2000

2

CONFIRM: a double-blind, placebo-controlled phase III clinical trial investigating the effect of nivolumab in patients with relapsed mesothelioma: study protocol for a randomised controlled trial

Fennell, Dean A., Kirkpatrick, Emma, Cozens, Kelly, Nye, Mavis, Lester, Jason, Hanna, Gerard, Steele, Nicola, Szlosarek, Peter, Danson, Sarah, Lord, Joanne, Ottensmeier, Christian, Barnes, Daniel, Hil

Journal:

Year:

2018

Language:

english

File:

PDF, 1.02 MB

english, 2018

3

Rewiring urea cycle metabolism in cancer to support anabolism

Keshet, Rom, Szlosarek, Peter, Carracedo, Arkaitz, Erez, Ayelet

Journal:

Nature Reviews Cancer

Year:

2018

Language:

english

File:

PDF, 1.39 MB

english, 2018

4

Energy efficiency of ropeways: a model-based analysis

Szlosarek, Robert, Yan, Chenguang, Kröger, Matthias, Nußbaumer, Christian

Journal:

Public Transport

Year:

2019

File:

PDF, 1.48 MB

2019

5

Aberrant regulation of argininosuccinate synthetase by TNF-α in human epithelial ovarian cancer

Peter W. Szlosarek, Matthew J. Grimshaw, George D. Wilbanks, Thorsten Hagemann, Julia L. Wilson, Frances Burke, Gordon Stamp, Frances R. Balkwill

Journal:

International Journal of Cancer

Year:

2007

Language:

english

File:

PDF, 321 KB

english, 2007

6

Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer

Linda J. Nicholson, Paul R. Smith, Louise Hiller, Peter W. Szlosarek, Christopher Kimberley, Jalid Sehouli, Dominique Koensgen, Alexander Mustea, Peter Schmid, Tim Crook

Journal:

International Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 629 KB

english, 2009

7

Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer

Barbara Delage, Dean A. Fennell, Linda Nicholson, Iain McNeish, Nicholas R. Lemoine, Tim Crook, Peter W. Szlosarek

Journal:

International Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 407 KB

english, 2010

8

Synchronous melanoma and renal carcinoma: a clinicopathological study of five cases

R. N. Matin, P. Szlosarek, J. M. McGregor, R. Cerio, C. A. Harwood

Journal:

Clinical and Experimental Dermatology

Year:

2012

Language:

english

File:

PDF, 51 KB

english, 2012

9

In vivo Loss of Expression of Argininosuccinate Synthetase in Malignant Pleural Mesothelioma Is a Biomarker for Susceptibility to Arginine Depletion

Szlosarek, P. W., Klabatsa, A., Pallaska, A., Sheaff, M., Smith, P., Crook, T., Grimshaw, M. J., Steele, J. P., Rudd, R. M., Balkwill, F. R.

Journal:

Clinical Cancer Research

Year:

2006

Language:

english

File:

PDF, 350 KB

english, 2006

10

Tumour necrosis factor-α as a tumour promoter

Peter Szlosarek, Kellie A. Charles, Frances R. Balkwill

Journal:

European Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 185 KB

english, 2006

11

Tumour necrosis factor α: a potential target for the therapy of solid tumours

Peter W Szlosarek, Frances R Balkwill

Journal:

The Lancet Oncology

Year:

2003

Language:

english

File:

PDF, 678 KB

english, 2003

12

221 A randomized phase II trial of pegylated arginine deaminase (ADI-PEG 20) in patients with malignant pleural mesothelioma

Szlosarek, P.W., Fennell, D.A., Rudd, R.M., Lind, M., Ranson, M., Hackshaw, A., Bomalaski, J.S., Steele, J.P.C.

Journal:

Year:

2006

Language:

english

File:

PDF, 48 KB

english, 2006

13

Chemotherapy-induced bowel obstruction in small cell lung cancer: a case report

Jermaine I. G. Coward, Nicola-Louise Ding, Roger Feakins, Hermant Kocher, Sanjay Popat, Piotr W. Szlosarek

Journal:

Medical Oncology

Year:

2012

Language:

english

File:

PDF, 192 KB

english, 2012

14

Metabolic Response to Pegylated Arginine Deiminase in Mesothelioma With Promoter Methylation of Argininosuccinate Synthetase

Szlosarek, P. W., Luong, P., Phillips, M. M., Baccarini, M., Ellis, S., Szyszko, T., Sheaff, M. T., Avril, N.

Journal:

Journal of Clinical Oncology

Year:

2013

Language:

english

File:

PDF, 479 KB

english, 2013

15

50 Systemic therapy in the management of non small cell lung cancer (NSCLC): The real world experience

Lewis, A., Hough, N., Woolf, D.K., Trehy, R., Kolotia, B., Reeves, A., Szlosarek, P.W., Wells, P., Steele, J.

Journal:

Year:

2013

Language:

english

File:

PDF, 45 KB

english, 2013

16

188 Three years experience of chemotherapy for small cell lung cancer at a tertiary referral centre

Hough, N., Lewis, A., Woolf, D.K., Trehy, R., Kolotia, B., Reeves, A., Szlosarek, P.W., Wells, P., Steele, J.

Journal:

Year:

2013

Language:

english

File:

PDF, 43 KB

english, 2013

17

222 MesobanK – a UK based bioresource for malignant mesothelioma

Rintoul, R.C., Rassl, D.M., Maskell, N., Gittins, J., Szlosarek, P.W., Kerr, K.M., Booton, R., Hughes, V., Fennell, D.A., Marciniak, S.J.

Journal:

Year:

2014

Language:

english

File:

PDF, 50 KB

english, 2014

18

Arginine deprivation and autophagic cell death in cancer: Fig. 1.

Szlosarek, Peter Wojciech

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 627 KB

english, 2014

19

Rewiring Mitochondrial Pyruvate Metabolism: Switching Off the Light in Cancer Cells?

Szlosarek, Peter W., Lee, SukJun, Pollard, Patrick J.

Journal:

Year:

2014

Language:

english

File:

PDF, 329 KB

english, 2014

20

Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma

Syed, N, Langer, J, Janczar, K, Singh, P, Lo Nigro, C, Lattanzio, L, Coley, H M, Hatzimichael, E, Bomalaski, J, Szlosarek, P, Awad, M, O'Neil, K, Roncaroli, F, Crook, T

Journal:

Cell Death and Disease

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

21

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

Wang, H, Lee, S, Nigro, C Lo, Lattanzio, L, Merlano, M, Monteverde, M, Matin, R, Purdie, K, Mladkova, N, Bergamaschi, D, Harwood, C, Syed, N, Szlosarek, P, Briasoulis, E, McHugh, A, Thompson, A, Evans

Journal:

British Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 577 KB

english, 2012

22

Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer

Lim, S L, Smith, P, Syed, N, Coens, C, Wong, H, van der Burg, M, Szlosarek, P, Crook, T, Green, J A

Journal:

British Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 131 KB

english, 2008

23

Polo-like Kinase Plk2 Is an Epigenetic Determinant of Chemosensitivity and Clinical Outcomes in Ovarian Cancer

Syed, N., Coley, H. M., Sehouli, J., Koensgen, D., Mustea, A., Szlosarek, P., McNeish, I., Blagden, S. P., Schmid, P., Lovell, D. P., Hatzimichael, E., Crook, T.

Journal:

Cancer Research

Year:

2011

Language:

english

File:

PDF, 2.00 MB

english, 2011

24

Expression and regulation of tumor necrosis factor in normal and malignant ovarian epithelium

Szlosarek, P. W.

Journal:

Molecular Cancer Therapeutics

Year:

2006

Language:

english

File:

PDF, 352 KB

english, 2006

25

Uveal Melanoma UK National Guidelines

Nathan, P., Cohen, V., Coupland, S., Curtis, K., Damato, B., Evans, J., Fenwick, S., Kirkpatrick, L., Li, O., Marshall, E., McGuirk, K., Ottensmeier, C., Pearce, N., Salvi, S., Stedman, B., Szlosarek,

Journal:

European Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 376 KB

english, 2015

26

New Polish Writing || Exiled

Artur Szlosarek and Ela Kotkowska-Atkinson

Journal:

Year:

2000

Language:

english

File:

PDF, 127 KB

english, 2000

27

Mechanical Testing of Flow Drill Screw Joints Between Fibre-Reinforced Plastics and Metals

Szlosarek, Robert, Karall, Thomas, Enzinger, Norbert, Hahne, Clemens, Meyer, Nils

Journal:

Materials Testing

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

28

The role of new PET tracers for lung cancer

Szyszko, Teresa A., Yip, Connie, Szlosarek, Peter, Goh, Vicky, Cook, Gary J.R.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.76 MB

english, 2016

29

New Polish Writing || Polish Poem

Artur Szlosarek

Journal:

Year:

2000

Language:

english

File:

PDF, 122 KB

english, 2000

30

Clinical activity and safety of Pembrolizumab in Ipilimumab pre-treated patients with uveal melanoma

Karydis, Ioannis, Chan, Pui Ying, Wheater, Matthew, Arriola, Edurne, Szlosarek, Peter W., Ottensmeier, Christian H.

Journal:

Year:

2016

Language:

english

File:

PDF, 2.83 MB

english, 2016

31

Effective treatment of a patient with a high-grade endometrial stromal sarcoma with an accelerated regimen of carboplatin and paclitaxel

Szlosarek, Piotr W, Lofts, Fiona J, Pettengell, Ruth, Carter, Paul, Young, Martin, Harmer, Clive

Journal:

Anti-Cancer Drugs

Year:

2000

Language:

english

File:

PDF, 166 KB

english, 2000

32

A randomized phase II trial of SRL172 (Mycobacterium vaccae) ± low-dose interleukin-2 in the treatment of metastatic malignant melanoma

Nicholson, S, Guile, K, John, J, Clarke, I A, Diffley, J, Donnellan, P, Michael, A, Szlosarek, P, Dalgleish, A G

Journal:

Melanoma Research

Year:

2003

Language:

english

File:

PDF, 81 KB

english, 2003

33

Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1

Locke, Matthew, Ghazaly, Essam, Freitas, Marta O., Mitsinga, Mikaella, Lattanzio, Laura, Lo Nigro, Cristiana, Nagano, Ai, Wang, Jun, Chelala, Claude, Szlosarek, Peter, Martin, Sarah A.

Journal:

Year:

2016

Language:

english

File:

PDF, 2.14 MB

english, 2016

34

Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1–Deficient Malignant Pleural Mesothelioma

Szlosarek, Peter W., Steele, Jeremy P., Nolan, Luke, Gilligan, David, Taylor, Paul, Spicer, James, Lind, Michael, Mitra, Sankhasuvra, Shamash, Jonathan, Phillips, Melissa M., Luong, Phuong, Payne, Sar

Journal:

Year:

2016

Language:

english

File:

PDF, 437 KB

english, 2016

35

Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20)

Burrows, Natalie, Cane, Gaelle, Robson, Mathew, Gaude, Edoardo, J. Howat, William, Szlosarek, Peter W., Pedley, R. Barbara, Frezza, Christian, Ashcroft, Margaret, Maxwell, Patrick H.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 2.23 MB

english, 2016

36

Development of carbon fibre-reinforced plastic (CFRP) crash absorbers with stable crushing behaviour considering the connection to the bumper system

Szlosarek, R., Bombis, F., Mühler, M., Kröger, M., Karall, T.

Journal:

Materialwissenschaft und Werkstofftechnik

Year:

2016

File:

PDF, 561 KB

2016

37

A major responder to ipilimumab and nivolumab in metastatic uveal melanoma with concomitant autoimmunity

Chan, Pui Ying, Hall, Peter, Hay, Gordon, Cohen, Victoria M L, Szlosarek, Peter W

Journal:

Pigment Cell & Melanoma Research

Year:

2017

Language:

english

File:

PDF, 454 KB

english, 2017

38

A fracture angle based three-dimensional damage model for unidirectional fibre-reinforced plastics

Szlosarek, Robert

Journal:

Year:

2016

Language:

english

File:

PDF, 299 KB

english, 2016

39

PUB035 CONFIRM: A Phase III Randomized Trial to Evaluate the Efficacy of Nivolumab versus Placebo in Relapsed Mesothelioma

Fennell, D., Kirkpatrick, E., Cozens, K., Danson, S., Hanna, G., Lester, J., Lord, J., Nye, M., Ottensmeier, C., Szlosarek, P., Steele, N., Kalevras, M., Maishman, T., Griffiths, G.

Journal:

Journal of Thoracic Oncology

Year:

2017

Language:

english

File:

PDF, 270 KB

english, 2017

40

MA 19.05 Pegylated Arginine Deiminase Potentiates PD-1/PD-L1 Immune Checkpoint Blockade in Malignant Mesothelioma

Szlosarek, P., Khadeir, R., Sheaff, M., Locke, M., Lau, K., Wu, B., Bomalaski, J., Martin, S., Quezada, S.

Journal:

Journal of Thoracic Oncology

Year:

2017

Language:

english

File:

PDF, 182 KB

english, 2017

41

Rituximab in the treatment of pembrolizumab-induced myasthenia gravis

Crusz, S.M., Radunovic, A., Shepherd, S., Shah, S., Newey, V., Phillips, M., Lim, L., Powles, T., Szlosarek, P.W., Shamash, J., Rashid, S.

Journal:

European Journal of Cancer

Year:

2018

File:

PDF, 242 KB

2018

42

Rituximab in the treatment of pembrolizumab-induced myasthenia gravis

Crusz, S.M., Radunovic, A., Shepherd, S., Shah, S., Newey, V., Phillips, M., Lim, L., Powles, T., Szlosarek, P.W., Shamash, J., Rashid, S.

Journal:

European Journal of Cancer

Year:

2018

Language:

english

File:

PDF, 242 KB

english, 2018

43

Collagen Prolyl Hydroxylases Are Bifunctional Growth Regulators in Melanoma

Atkinson, Aithne, Renziehausen, Alexander, Wang, Hexiao, Lo Nigro, Cristiana, Lattanzio, Laura, Merlano, Marco, Rao, Bhavya, Weir, Lynda, Evans, Alan, Matin, Rubeta, Harwood, Catherine, Szlosarek, Pet

Journal:

The Journal of Investigative Dermatology

Year:

2018

File:

PDF, 1.59 MB

2018

44

Collagen Prolyl Hydroxylases Are Bifunctional Growth Regulators in Melanoma

Atkinson, Aithne, Renziehausen, Alexander, Wang, Hexiao, Lo Nigro, Cristiana, Lattanzio, Laura, Merlano, Marco, Rao, Bhavya, Weir, Lynda, Evans, Alan, Matin, Rubeta, Harwood, Catherine, Szlosarek, Pet

Journal:

The Journal of Investigative Dermatology

Year:

2018

Language:

english

File:

PDF, 1.59 MB

english, 2018

45

CONFIRM: a phase III randomised trial to evaluate the efficacy of nivolumab versus placebo in relapsed mesothelioma

Hanna, G., Griffiths, G., Kirkpatrick, E.V., Cozens, K., Kalevras, M., Maishman, T., Danson, S., Lester, J., Ottensmeier, C., Steele, N., Szlosarek, P., Lord, J., Nye, M., Fennell, D.

Journal:

Year:

2018

Language:

english

File:

PDF, 43 KB

english, 2018

46

ES03.04 Pegargiminase to Treat Mesothelioma

Journal:

Journal of Thoracic Oncology

Year:

2019

File:

PDF, 138 KB

2019

47

Phase II Study of Arginine Deprivation Therapy with Pegargiminase in Patients with Relapsed Sensitive or Refractory Small Cell Lung Cancer.

Hall, Peter E., Ready, Neal, Johnston, Amanda, Bomalaski, John S., Venhaus, Ralph R., Sheaff, Michael, Krug, Lee, Szlosarek, Peter W.

Journal:

Clinical Lung Cancer

Year:

2020

File:

PDF, 1.01 MB

2020

48

Design and construction of a simplified, gas-driven, pressure-controlled emergency ventilator

Szlosarek, R., Teichert, R., Wetzel, A., Fichtner, A., Reuter, F., KrÃ¶ger, M.

Journal:

African Journal of Emergency Medicine

Year:

2020

File:

PDF, 60 KB

2020